Prof. Dr. Adam Lange
Research interests
- solid-state NMR method development
- biophysical and chemical applications
- membrane protein structure, dynamics, and function
- intramembrane proteolysis
- selective and non-selective cation channels
- supramolecular protein assemblies
Research Units in UniSysCat
Awards (selection)
| 2016 | Founders’ Medal of the International Council on Magnetic Resonance in Biological Systems (ICMRBS) |
| 2013 | ERC Starting Grant |
| 2009 | Emmy Noether stipend |
| 2007 | EMBO long-term fellowship |
| 2006 | Otto Hahn Medal of the Max Planck Society |
| 2006 | Ernst Award of the German Chemical Society |
Prof. Dr. Adam Lange
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
Robert-Rössle-Str. 10
13125 Berlin
alange(at)fmp-berlin.de
www.leibniz-fmp.de
Publications (selection)
A. Lange, K. Giller, S. Hornig, M. F. Martin-Eauclaire, O. Pongs, S. Becker, and M. Baldus, Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR, Nature 2006, 440, 959-962.
C. Wasmer, A. Lange, H. Van Melckebeke, A. B. Siemer, R. Riek, and B. H. Meier, Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core, Science 2008, 319, 1523-1526.
A. Loquet, N. G. Sgourakis, R. Gupta, K. Giller, D. Riedel, C. Goosmann, C. Griesinger, M. Kolbe, D. Baker, S. Becker, and A. Lange, Atomic model of the type III secretion system needle, Nature 2012, 486, 276-279.
V. Daebel, S. Chinnathambi, J. Biernat, M. Schwalbe, B. Habenstein, A. Loquet, E. Akoury, K. Tepper, H. Müller, M. Baldus, C. Griesinger, M. Zweckstetter, E. Mandelkow, V. Vijayan, and A. Lange, b-sheet core of tau paired helical filaments revealed by solid-state NMR, Journal of the American Chemical Society 2012, 134, 13982-13989.
J.-P. Demers, B. Habenstein, A. Loquet, S. K. Vasa, K. Giller, S. Becker, D. Baker, A. Lange*, and N. G. Sgourakis*, High-resolution structure of the Shigella type-III secretion needle determined by solid-state NMR and cryo-electron microscopy, Nature Communications 2014, 5, 4976.
S. Vasa, L. Lin, C. Shi, B. Habenstein, D. Riedel, J. Kühn, M. Thanbichler, and A. Lange, β-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR, Proceedings of the National Academy of Sciences 2015, 112, E127-E136.
C. Shi, P. Fricke, L. Lin, V. Chevelkov, M. Wegstroth, K. Giller, S. Becker, M. Thanbichler, and A. Lange, Atomic-resolution structure of cytoskeletal bactofilin by solid-state NMR, Science Advances 2015, 1, e1501087.
P. Fricke, V. Chevelkov, M. Zinke, K. Giller, S. Becker, and A. Lange, Backbone assignment of perdeuterated proteins by solid-state NMR using proton-detection and ultrafast magic-angle spinning, Nature Protocols, 2017, 12, 764-782.
M. Zinke, P. Fricke, C. Samson, S. Hwang, J. S. Wall, S. Lange, S. Zinn-Justin, and A. Lange, Bacteriophage tail tube assembly studied by proton-detected 4D solid-state NMR, Angewandte Chemie – International Edition 2017, 56, 9497-9501.
C. Shi, Y. He, K. Hendriks, B. L. de Groot, X. Cai, C. Tian, A. Lange, H. Sun, A single NaK channel conformation is not enough for non-selective ion conduction, Nature Communications 2018, 9, 717.