Prof. Dr. Peter Hegemann
Research interests
- molecular photobiology: blue-light receptors, unusual rhodopsins
- biochemistry
- algal biotechnology
- optogentics
Research Units in UniSysCat
Awards (selection)
| 2018 | Otto Warburg Medaille der GBM (German Society for Biochemistry and Mol. Biology) |
| 2017 | Leopoldina Mendel Medaille, Halle |
| 2017 | Harvey Prize, Technion, Haifa (Israel) |
| 2016 | Massry Prize, Meira and Shaul G. Massry Foundation, Los Angeles (USA) |
| 2016 | Honorary Bonhoeffer Prize Lecture, Göttingen |
| 2016 | European Research Council (ERC) Advanced Grant on: Mechanism of Enzyme Rhodopsin Activation (MERA) |
| 2016 | Hector Science Award and Hector Fellow, Heidelberg |
| 2015 | Mayors Science Prize of Berlin |
| 2014 | Member of the Academy of Science and Engineering (acatech) |
| 2014 | Member of the Berlin-Brandenburg Academy of Sciences and Humanities |
| 2014 | Member of the European Molecular Biology Organization EMBO |
| 2013 | Brain Prize of the G. Lundbeck European Brain Research Prize Foundation, Copenhagen (Denmark) |
| 2013 | Louis-Jeantet Award, Geneva (Switzerland) |
| 2013 | Leibniz Prize of the German Research Foundation (DFG) |
| 2013 | Member of the German National Academy of Sciences, Leopoldina |
Prof. Dr. Peter Hegemann
HU Berlin
Department of Biology
Invalidenstraße 42
10115 Berlin
hegemann(at)rz.hu-berlin.de
www.biologie.hu-berlin.de/hegemann-peter
UniSysCat Publications
- Experimental Assessment of the Electronic and Geometrical Structure of a Near-Infrared Absorbing and Highly Fluorescent Microbial Rhodopsin, M. Broser, T. Andruniów, A. Kraskov, R. Palombo, S. Katz, M. Kloz, J. Dostál, C. Bernardo, J. T. M. Kennis, P. Hegemann, M. Olivucci, P. Hildebrandt, The Journal of Physical Chemistry Letters 2023, 14, 9291–9295, 10.1021/acs.jpclett.3c02167
- Diversity of rhodopsin cyclases in zoospore-forming fungi, M. Broser, W. Busse, A. Spreen, M. Reh, Y. A. Bernal Sierra, S. Hwang, T. Utesch, H. Sun, P. Hegemann, Proceedings of the National Academy of Sciences 2023, 120, 10.1073/pnas.2310600120
- QuasAr Odyssey: the origin of fluorescence and its voltage sensitivity in microbial rhodopsins, A. Silapetere, S. Hwang, Y. Hontani, R. G. Fernandez Lahore, J. Balke, F. V. Escobar, M. Tros, P. E. Konold, R. Matis, R. Croce, P. J. Walla, P. Hildebrandt, U. Alexiev, J. T. M. Kennis, H. Sun, T. Utesch, P. Hegemann, Nature Communications 2022, 13, 10.1038/s41467-022-33084-4
- Dual Photoisomerization on Distinct Potential Energy Surfaces in a UV-Absorbing Rhodopsin, Y. Hontani, M. Broser, M. Luck, J. Weißenborn, M. Kloz, P. Hegemann, J. T. M. Kennis, Journal of the American Chemical Society 2020, 142, 11464–11473, 10.1021/jacs.0c03229
- Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor Archon2, A. Penzkofer, A. Silapetere, P. Hegemann, International Journal of Molecular Sciences 2020, 21, 6576–0, 10.3390/ijms21186576
- Matters of class: coming of age of class III and IV lanthipeptides, J. D. Hegemann, R. D. Süssmuth, RSC Chemical Biology 2020, 1, 110–127, 10.1039/d0cb00073f
- Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1, Penzkofer, Silapetere, Hegemann, International Journal of Molecular Sciences 2019, 20, 4086–0, 10.3390/ijms20174086
- Photocycle Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1, A. Penzkofer, A. Silapetere, P. Hegemann, International Journal of Molecular Sciences 2019, 21, 160–0, 10.3390/ijms21010160
- Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2, J. Kuhne, J. Vierock, S. A. Tennigkeit, M. A. Dreier, J. Wietek, D. Petersen, K. Gavriljuk, S. F. El-Mashtoly, P. Hegemann, K. Gerwert, Proceedings of the National Academy of Sciences 2019, 116, 9380–9389, 10.1073/pnas.1818707116
- Tracking Pore Hydration in Channelrhodopsin by Site-Directed Infrared-Active Azido Probes, B. S. Krause, J. C. D. Kaufmann, J. Kuhne, J. Vierock, T. Huber, T. P. Sakmar, K. Gerwert, F. J. Bartl, P. Hegemann, Biochemistry 2019, 58, 1275–1286, 10.1021/acs.biochem.8b01211
- Engineered Passive Potassium Conductance in the KR2 Sodium Pump, A. Vogt, A. Silapetere, C. Grimm, F. Heiser, M. Ancina Möller, P. Hegemann, Biophysical Journal 2019, 116, 1941–1951, 10.1016/j.bpj.2019.04.001
- MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins, J. Oppermann, P. Fischer, A. Silapetere, B. Liepe, S. Rodriguez-Rozada, J. Flores-Uribe, E. Peter, A. Keidel, J. Vierock, J. Kaufmann, M. Broser, M. Luck, F. Bartl, P. Hildebrandt, J. S. Wiegert, O. Béjà, P. Hegemann, J. Wietek, Nature Communications 2019, 10, 10.1038/s41467-019-11322-6
- Design of a light-gated proton channel based on the crystal structure of rhodopsin, R. Fudim, M. Szczepek, J. Vierock, A. Vogt, A. Schmidt, G. Kleinau, P. Fischer, F. Bartl, P. Scheerer, P. Hegemann, Science Signaling 2019, 12, 10.1126/scisignal.aav4203
Publications (selection)
K. Deisseroth, P. Hegemann, The form and function of channelrhodopsin, Science 2017, 357, 6356.
D. Petroutsos, R. Tokutsu, S. Maruyama, S. Flori, A. Greiner, L. Magneschi, L. Cusant, T. Kottke, M. Mittag, P. Hegemann, G. Finazzi, J. Minagawa, A blue light photoreceptor mediates the feedback regulation of photosynthesis, Nature 2016, 537, 563–566.
N. Takahashi, T. Oertner, P. Hegemann, M. E. Larkum, Perceptual detection depends on a dendritic mechanism in cortical pyramidal cells, Science 2016, 354, 1587–1590.
E. A. Ferenczi, J. Vierock, K. Atsuta-Tsunoda, S. P. Tsunoda, C. Ramakrishnan, C. Gorini, K. Thompson, S. Y. Lee, A. Berndt, C. Perry, S. Minniberger, A. Vogt, J. Mattis, R. Prakash, S. Delp, K. Deisseroth, P. Hegemann, Optogenetic approaches addressing extracellular modulation of neural excitability, Scientific Reports 2016, 6, 23947.
D. Petroutsos, R. Tokutsu, S. Maruyama, S. Flori, A. Greiner, L. Magneschi, L. Cusant, T. Kottke, M. Mittag, P. Hegemann, G. Finazzi, J. Minagawa, A blue light photoreceptor mediates the feedback regulation of photosynthesis, Nature 2016, 537, 563–566.
B. R. Rost, F. Schneider, M. K. Grauel, C. Wozny, C.G. Bentz, A. Blessing, T. Rosenmund, T. J. Jentsch, D. Schmitz, P. Hegemann, C. Rosenmund, Optogenetic acidification of synaptic vesicles and lysosomes, Nature Neuroscience 2015, 18, 1845–1852.
U. Scheib, K. Stehfest, C. E. Gee, H. G. Korschen, R. Fudim, T. G. Oertner, P. Hegemann, The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling, Science Signaling 2015, 8, rs8.
J. Wietek, J. S. Wiegert, N. Adeishvili, F. Schneider, H. Watanabe, S. P. Tsunoda, A. Vogt, M. Elstner, T. G. Oertner, P. Hegemann, Conversion of channelrhodopsin into a light-gated chloride channel, Science 2015, 344, 409–412.
O. Yizhar, L. E. Fenno, M. Prigge, F. Schneider, T. J. Davidson, D. J. O’Shea, V. S. Sohal, I. Goshen, J. Finkelstein, J. T. Paz, K. Stehfest, R. Fudim, C. Ramakrishnan, J. R. Huguenard, P. Hegemann, K. Deisseroth, Neocortical excitation/inhibition balance in information processing and social dysfunction, Nature 2011, 477, 171–178.
F. Zhang, J. Vierock, O. Yizhar, L. E. Fenno, S. Tsunoda, A. Kianianmomeni, M. Prigge, A. Berndt, Cushman, J. Polle, J. Magnuson, P. Hegemann, K. Deisseroth, The microbial opsin family of optogenetic tools, Cell 2011, 147, 1446–1457.
Patents
K. Deisseroth, O. Yizhar, L. Gunaydin, P. Hegemann, A. Berndt, Optically-based stimulation of target cells and modifications thereto, 2009, US20110311489 A1, US9309296 B2, WO/2010/056970.
K. Deisseroth, L. Fenno, P. Hegemann, M. Prigge, O. Yizhar, Light-activated chimeric opsins and methods of using the same, 2012, WO2012061676, PCT/US2011/059276, US9175095, US 15/147,772.
K. Deisseroth, E. Ferencczi, P. Hegemann, System for modulating the membrane potential of a cell, comprises nucleotide sequences encoding a light-activated protein and a response protein that responds to the passage of the ion through the cell membrane, 2014, WO2014179331A2.
K. Deisseroth, O. Yizhar, L. Fenno, P. Hegemann, M. Prigge, New Animal cell e.g. muscle cell comprising light-activated protein expressed on cell membrane, where protein is e.g. chimeric protein (Volvox channelrhodopsin-1) from Volvox carteri used for e.g. selectively depolarizing excitatory neurons, 2011, WO2012066179-A2, AU2011323226-A1, CA2816971-A1, WO2012061679-A3, EP2635108-A2, JP2014500716-W, CN103492564-A.